Higher Baseline Proinflammatory Cytokines Mark Poor Antidepressant Response in Bipolar Disorder.

@article{Benedetti2017HigherBP,
  title={Higher Baseline Proinflammatory Cytokines Mark Poor Antidepressant Response in Bipolar Disorder.},
  author={Francesco Benedetti and Sara Poletti and Thomas A. Hoogenboezem and Clara Locatelli and Harm J. de Wit and Annemarie J. M. Wijkhuijs and Cristina F. Colombo and Hemmo A. Drexhage},
  journal={The Journal of clinical psychiatry},
  year={2017},
  volume={78 8},
  pages={
          e986-e993
        }
}
BACKGROUND The clinical relevance of raised levels of circulating cytokines in bipolar disorder is still unclear. Cytokines influence neurotransmitters, neuroplasticity, and white matter integrity. An inconsistent literature suggests that higher cytokine levels could hamper antidepressant response. Total sleep deprivation (TSD) and light therapy (LT) prompt a rapid antidepressant response and can provide a model treatment to study predictors of response. METHODS We studied at baseline 15… CONTINUE READING
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