High yield production of D-xylonic acid from D-xylose using engineered Escherichia coli.

@article{Liu2012HighYP,
  title={High yield production of D-xylonic acid from D-xylose using engineered Escherichia coli.},
  author={Huaiwei Liu and Kris Ni{\~n}o G. Valdehuesa and Grace Nisola and Kristine Rose M. Ramos and Wook-Jin Chung},
  journal={Bioresource technology},
  year={2012},
  volume={115},
  pages={244-8}
}
An engineered Escherichia coli was constructed to produce D-xylonic acid, one of the top 30 high-value chemicals identified by US Department of Energy. The native pathway for D-xylose catabolism in E. coli W3110 was blocked by disrupting xylose isomerase (XI) and xylulose kinase (XK) genes. The native pathway for xylonic acid catabolism was also blocked by disrupting two genes both encoding xylonic acid dehydratase (yagE and yjhG). Through the introduction of a D-xylose dehydrogenase from… CONTINUE READING

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