High yield expression and secretion of the ovine pregnancy recognition hormone interferon-tau by Pichia pastoris.

@article{Heeke1996HighYE,
  title={High yield expression and secretion of the ovine pregnancy recognition hormone interferon-tau by Pichia pastoris.},
  author={G Van Heeke and Troy L. Ott and Alfred Strauss and D Ammaturo and Fuller W Bazer},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={1996},
  volume={16 2},
  pages={
          119-26
        }
}
The early conceptus (embryo and associated membranes) of domestic ruminats signals its presence to the maternal uterus through production of interferon-tau (IFN-tau). Production of IFN-tau ensures continued production of progesterone, the hormone of pregnancy, by the ovarian corpus luteum. This paper reports the high-level expression and efficient secretion of biologically active recombinant ovine IFN-tau (rOvIFN-tau) by Pichia pastoris. The developed method produces more than 80% pure… CONTINUE READING

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  • 2013
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