High yield bacterial expression of active c-Abl and c-Src tyrosine kinases.

  title={High yield bacterial expression of active c-Abl and c-Src tyrosine kinases.},
  author={Markus A. Seeliger and Matthew Young and Michael Henderson and Patricia Pellicena and D. King and Arnold M. Falick and John Kuriyan},
  journal={Protein science : a publication of the Protein Society},
  volume={14 12},
The Abl and Src tyrosine kinases are key signaling proteins that are of considerable interest as drug targets in cancer and many other diseases. The regulatory mechanisms that control the activity of these proteins are complex, and involve large-scale conformational changes in response to phosphorylation and other modulatory signals. The success of the Abl inhibitor imatinib in the treatment of chronic myelogenous leukemia has shown the potential of kinase inhibitors, but the rise of drug… CONTINUE READING
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