High within-patient variability in the clearance of tacrolimus is a risk factor for poor long-term outcome after kidney transplantation.

@article{Borra2010HighWV,
  title={High within-patient variability in the clearance of tacrolimus is a risk factor for poor long-term outcome after kidney transplantation.},
  author={Lennaert C P Borra and Joke I. Roodnat and Judith A Kal and Ron A. A. Math{\^o}t and Willem W Weimar and Teun van Gelder},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2010},
  volume={25 8},
  pages={2757-63}
}
BACKGROUND We hypothesized that a high within-patient variability in clearance of tacrolimus and mycophenolate mofetil (MMF) would put patients at risk for periods of over- or underimmunosuppression and would thus lead to long-term chronic allograft nephropathy and graft loss after transplantation. METHODS From 297 patients transplanted between 1 January 2000 and 31 December 2004, the within-patient variability in clearance was calculated from tacrolimus whole-blood concentrations and… CONTINUE READING

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