High vs low anxiety-related behavior rats: an animal model of extremes in trait anxiety.

@article{Landgraf2002HighVL,
  title={High vs low anxiety-related behavior rats: an animal model of extremes in trait anxiety.},
  author={Rainer Landgraf and Alexandra Wigger},
  journal={Behavior genetics},
  year={2002},
  volume={32 5},
  pages={301-14}
}
In addition to their robust difference in trait anxiety, as illustrated by a variety of behavioral tests, HAB and LAB rats differ in their stress coping strategies, the former being more susceptible and vulnerable to stressor exposure and preferring more passive strategies. HAB rats of either gender show signs of a hyper-reactive hypothalamic-pituitary-adrenocortical (HPA) axis, thus resembling psychiatric patients. As shown by in situ hybridization and microdialysis in freely behaving animals… CONTINUE READING

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