High von Willebrand factor levels increase the risk of first ischemic stroke: influence of ADAMTS13, inflammation, and genetic variability.

@article{Bongers2006HighVW,
  title={High von Willebrand factor levels increase the risk of first ischemic stroke: influence of ADAMTS13, inflammation, and genetic variability.},
  author={Tamara N Bongers and Moniek P M de Maat and Mary-Lou P J van Goor and Vinod Bhagwanbali and Huub H D M van Vliet and Encarna B. G{\'o}mez Garcia and Diederik W. J. Dippel and Frank W G Leebeek},
  journal={Stroke},
  year={2006},
  volume={37 11},
  pages={2672-7}
}
BACKGROUND AND PURPOSE Elevated von Willebrand factor (vWF) concentrations are associated with an increased risk of ischemic heart disease. Several factors influence vWF antigen levels and activity, including blood group, genetic variability, acute-phase response, and proteolysis by A Disintegrin and Metalloprotease with ThromboSpondin motif (ADAMTS13), a determinant of proteolytic cleavage of vWF. We assessed how these factors affect the relation between vWF and the occurrence of stroke to… CONTINUE READING
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Genetic variability of von Willebrand factor and risk of coronary heart disease: The Rotterdam Study

  • IM van der Meer, GJ Brouwers, +5 authors EB. Gomez Garcia
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