High viral burden restricts short-lived effector cell number at late times postinfection through increased natural regulatory T cell expansion.

@article{Amoah2013HighVB,
  title={High viral burden restricts short-lived effector cell number at late times postinfection through increased natural regulatory T cell expansion.},
  author={Samuel Amoah and Beth C. Holbrook and Rama D. Yammani and Martha A Alexander-Miller},
  journal={Journal of immunology},
  year={2013},
  volume={190 10},
  pages={5020-9}
}
Generating and maintaining a robust CD8(+) T cell response in the face of high viral burden is vital for host survival. Further, balancing the differentiation of effectors along the memory precursor effector cell pathway versus the short-lived effector cell (SLEC) pathway may be critical in controlling the outcome of virus infection with regard to clearance and establishing protection. Although recent studies have identified several factors that have the capacity to regulate effector CD8(+) T… CONTINUE READING