High versus low positive end-expiratory pressure during general anaesthesia for open abdominal surgery (PROVHILO trial): a multicentre randomised controlled trial.

@article{Hemmes2014HighVL,
  title={High versus low positive end-expiratory pressure during general anaesthesia for open abdominal surgery (PROVHILO trial): a multicentre randomised controlled trial.},
  author={Sabrine N. T. Hemmes and Marcelo Gama de Abreu and Paolo Pelosi and Marcus J. Schultz},
  journal={Lancet},
  year={2014},
  volume={384 9942},
  pages={
          495-503
        }
}
BACKGROUND The role of positive end-expiratory pressure in mechanical ventilation during general anaesthesia for surgery remains uncertain. Levels of pressure higher than 0 cm H2O might protect against postoperative pulmonary complications but could also cause intraoperative circulatory depression and lung injury from overdistension. We tested the hypothesis that a high level of positive end-expiratory pressure with recruitment manoeuvres protects against postoperative pulmonary complications… CONTINUE READING
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