High valent iron oxo intermediates might be involved during activation of ribonucleotide reductase: single oxygen atom donors generate the tyrosyl radical.

Abstract

The active form of protein B2, the small subunit of ribonucleotide reductase from E. Coli, contains a binuclear non heme iron center and a tyrosyl radical. MetB2 is an inactive form that lacks the radical but retains the Fe(III) center. We earlier proposed that the function of the iron center was to catalyze the one-electron oxidation of the tyrosine… (More)

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@article{Fontecave1990HighVI, title={High valent iron oxo intermediates might be involved during activation of ribonucleotide reductase: single oxygen atom donors generate the tyrosyl radical.}, author={Marc Fontecave and Catherine Gerez and Mohamed Abou El Atta and Andr{\'e} Jeunet}, journal={Biochemical and biophysical research communications}, year={1990}, volume={168 2}, pages={659-64} }