High urinary excretion of lipid peroxidation-derived DNA damage in patients with cancer-prone liver diseases.

@article{Nair2010HighUE,
  title={High urinary excretion of lipid peroxidation-derived DNA damage in patients with cancer-prone liver diseases.},
  author={J. Hariharan Nair and Petcharin Srivatanakul and Claudia Haas and Adisorn Jedpiyawongse and Thiravud Khuhaprema and Helmut Karl Seitz and Helmut Bartsch},
  journal={Mutation research},
  year={2010},
  volume={683 1-2},
  pages={23-8}
}
Chronic inflammatory processes induce oxidative and nitrative stress that trigger lipid peroxidation (LPO), whereby DNA-reactive aldehydes such as trans-4-hydroxy-2-nonenal (HNE) are generated. Miscoding etheno-modified DNA adducts including 1,N(6)-etheno-2'-deoxyadenosine (epsilondA) are formed by reaction of HNE with DNA-bases which are excreted in urine, following elimination from tissue DNA. An ultrasensitive and specific immunoprecipitation/HPLC-fluorescence detection method was developed… CONTINUE READING

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