High uric acid directly inhibits insulin signalling and induces insulin resistance.

@article{Zhu2014HighUA,
  title={High uric acid directly inhibits insulin signalling and induces insulin resistance.},
  author={Yuzhang Zhu and Yaqiu Hu and Tianliang Huang and Yongneng Zhang and Zhi Li and Chaohuan Luo and Yinfeng Luo and Huier Yuan and Ichiro Hisatome and Tetsuya Yamamoto and Jidong Cheng},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={447 4},
  pages={707-14}
}
BACKGROUND AND AIM Accumulating clinical evidence suggests that hyperuricemia is strongly associated with abnormal glucose metabolism and insulin resistance. However, how high uric acid (HUA) level causes insulin resistance remains unclear. We aimed to determine the direct role of HUA in insulin resistance in vitro and in vivo in mice. METHODS An acute hyperuricemia mouse model was created by potassium oxonate treatment, and the impact of HUA level on insulin resistance was investigated by… CONTINUE READING