High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene.

@article{TorresArzayus2004HighTI,
  title={High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene.},
  author={Maria I. Torres-Arzayus and Jaime Font de Mora and Jing Yuan and Francisca Vazquez and Roderick Bronson and Montserrat Ru{\'e} and William R Sellers and Myles Brown},
  journal={Cancer cell},
  year={2004},
  volume={6 3},
  pages={263-74}
}
The gene encoding AIB1, an estrogen receptor coactivator, is amplified in a subset of human breast cancers. Here we show that overexpression of AIB1 in transgenic mice (AIB1-tg) leads to mammary hypertrophy, hyperplasia, abnormal postweaning involution, and the development of malignant mammary tumors. Tumors are also increased in other organs, including the pituitary and uterus. AIB1 overexpression increases mammary IGF-I mRNA and serum IGF-I protein levels. In addition, IGF-I receptor and… CONTINUE READING
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