High tissue factor-expressing human monocytes carry low surface CD36: application to intersubject variability.

@article{Sovershaev2007HighTF,
  title={High tissue factor-expressing human monocytes carry low surface CD36: application to intersubject variability.},
  author={Mikhail A. Sovershaev and Elena M. Egorina and Franz X. E. Gruber and Jan Ole Olsen and Bjarne Osterud},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2007},
  volume={5 12},
  pages={2453-60}
}
BACKGROUND The 'high and low responder' phenomenon describes an intersubject variability in mononuclear cell (MNC) prothrombotic reactivity to lipopolysaccharide (LPS) stimulation. Because alterations in surface CD36 expression in monocytes were associated with impaired monocyte function, we studied the relationship between the levels of surface CD36 presentation and the prothrombotic reactivity of monocytes from high-responder (HR) and low-responder (LR) individuals. METHODS AND RESULTS The… CONTINUE READING