High-throughput variation detection and genotyping using microarrays.

  title={High-throughput variation detection and genotyping using microarrays.},
  author={David J. Cutler and Michael E. Zwick and Minerva M. Carrasquillo and Christopher T. Yohn and Katherine P. Tobin and Carl S. Kashuk and Debra J. H. Mathews and Nila Shah and Evan E. Eichler and J Anthony Warrington and Aravinda Chakravarti},
  journal={Genome research},
  volume={11 11},
The genetic dissection of complex traits may ultimately require a large number of SNPs to be genotyped in multiple individuals who exhibit phenotypic variation in a trait of interest. Microarray technology can enable rapid genotyping of variation specific to study samples. To facilitate their use, we have developed an automated statistical method (ABACUS) to analyze microarray hybridization data and applied this method to Affymetrix Variation Detection Arrays (VDAs). ABACUS provides a quality… CONTINUE READING
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