High-throughput tissue microarray analysis of cyclin E gene amplification and overexpression in urinary bladder cancer.

@article{Richter2000HighthroughputTM,
  title={High-throughput tissue microarray analysis of cyclin E gene amplification and overexpression in urinary bladder cancer.},
  author={Jan Richter and Urs Wagner and Juha Kononen and Andr{\'e} Fijan and James Bruderer and Ulrico Schmid and Daniel Ackermann and Robert Maurer and G{\"o}ran Alund and Hartmut Kn{\"o}nagel and Marcus Rist and Kim A Wilber and Mariano Anabitarte and F. Hering and Th Hardmeier and A J Schoenenberger and Renata Flury and Peter J{\"a}ger and Jean Luc Fehr and Peter Schraml and Holger Moch and Michael J{\"o}rg Mihatsch and T. Christian Gasser and Olli Kallioniemi and Guido Sauter},
  journal={The American journal of pathology},
  year={2000},
  volume={157 3},
  pages={787-94}
}
Studies by comparative genomic hybridization revealed that the 19q13 chromosomal region is frequently amplified in bladder cancer. The cyclin E gene (CCNE), coding for a regulatory subunit of cyclin-dependent kinase 2, has been mapped to 19q13. To investigate the role of cyclin E alterations in bladder cancer, a tissue microarray of 2,317 specimens from 1,842 bladder cancer patients was constructed and analyzed for CCNE amplification by fluorescence in situ hybridization and for cyclin-E… CONTINUE READING

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