High-throughput single-strand conformation polymorphism analysis by automated capillary electrophoresis: robust multiplex analysis and pattern-based identification of allelic variants.

@article{Larsen1999HighthroughputSC,
  title={High-throughput single-strand conformation polymorphism analysis by automated capillary electrophoresis: robust multiplex analysis and pattern-based identification of allelic variants.},
  author={Lars Allan Larsen and Michael Christiansen and Jens Vuust and Paal Skytt Andersen},
  journal={Human mutation},
  year={1999},
  volume={13 4},
  pages={
          318-27
        }
}
Genetic diagnosis of an inherited disease or cancer often involves analysis for unknown point mutations in several genes; therefore, rapid and automated techniques that can process a large number of samples are needed. We describe a method for high-throughput single-strand conformation polymorphism (SSCP) analysis using automated capillary electrophoresis. The operating temperature of a commercially available capillary electrophoresis instrument (ABI PRISM 310) was expanded by installation of a… CONTINUE READING

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