High-throughput simultaneous screen and counterscreen identifies homoharringtonine as synthetic lethal with von Hippel-Lindau loss in renal cell carcinoma

@inproceedings{Wolff2015HighthroughputSS,
  title={High-throughput simultaneous screen and counterscreen identifies homoharringtonine as synthetic lethal with von Hippel-Lindau loss in renal cell carcinoma},
  author={Nicholas C. Wolff and Andrea Pav{\'i}a-Jim{\'e}nez and Vanina Toffessi Tcheuyap and Shane Alexander and Mridula Vishwanath and Alana Christie and Xian-Jin Xie and Noelle S Williams and Payal Kapur and Bruce A. Posner and Ren{\'e}e M. McKay and James Brugarolas},
  booktitle={Oncotarget},
  year={2015}
}
Renal cell carcinoma (RCC) accounts for 85% of primary renal neoplasms, and is rarely curable when metastatic. Approximately 70% of RCCs are clear-cell type (ccRCC), and in >80% the von Hippel-Lindau (VHL) gene is mutated or silenced. We developed a novel, high-content, screening strategy for the identification of small molecules that are synthetic lethal with genes mutated in cancer. In this strategy, the screen and counterscreen are conducted simultaneously by differentially labeling mutant… CONTINUE READING
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