High-throughput screening to identify inhibitors of lysine demethylases.

@article{Gale2015HighthroughputST,
  title={High-throughput screening to identify inhibitors of lysine demethylases.},
  author={M. Gale and Q. Yan},
  journal={Epigenomics},
  year={2015},
  volume={7 1},
  pages={
          57-65
        }
}
Lysine demethylases (KDMs) are epigenetic regulators whose dysfunction is implicated in the pathology of many human diseases including various types of cancer, inflammation and X-linked intellectual disability. Particular demethylases have been identified as promising therapeutic targets, and tremendous efforts are being devoted toward developing suitable small-molecule inhibitors for clinical and research use. Several High-throughput screening strategies have been developed to screen for small… Expand
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References

SHOWING 1-10 OF 45 REFERENCES
Histone lysine demethylases as targets for anticancer therapy
  • 333
A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth
  • 187
  • PDF
A miniaturized screen for inhibitors of Jumonji histone demethylases.
  • 70
Screening Assays for Epigenetic Targets Using Native Histones as Substrates
  • 17
  • PDF
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