High-throughput screening to identify inhibitors of lysine demethylases.

@article{Gale2015HighthroughputST,
  title={High-throughput screening to identify inhibitors of lysine demethylases.},
  author={Molly Gale and Qin Yan},
  journal={Epigenomics},
  year={2015},
  volume={7 1},
  pages={
          57-65
        }
}
Lysine demethylases (KDMs) are epigenetic regulators whose dysfunction is implicated in the pathology of many human diseases including various types of cancer, inflammation and X-linked intellectual disability. Particular demethylases have been identified as promising therapeutic targets, and tremendous efforts are being devoted toward developing suitable small-molecule inhibitors for clinical and research use. Several High-throughput screening strategies have been developed to screen for small… CONTINUE READING
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