High-throughput screening of stabilizers for respiratory syncytial virus: identification of stabilizers and their effects on the conformational thermostability of viral particles.

@article{Ausar2007HighthroughputSO,
  title={High-throughput screening of stabilizers for respiratory syncytial virus: identification of stabilizers and their effects on the conformational thermostability of viral particles.},
  author={Salvador Fernando Ausar and Marianela Espina and Julie Brock and Nagarajan Thyagarayapuran and Robert Repetto and Lakshmi Khandke and C. Russell Middaugh},
  journal={Human vaccines},
  year={2007},
  volume={3 3},
  pages={94-103}
}
Respiratory syncytial virus (RSV) is the leading cause of severe respiratory infection in children worldwide. Recombinant live attenuated viral preparations are one of the most promising strategies for vaccination but they typically possess poor thermostability. In this work, a library of compounds was screened and stabilizers were selected based on their ability to inhibit the aggregation of RSV perturbed at 56 degrees C. After screening and selection of excipients, the conformational… CONTINUE READING

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