High-throughput screening of small molecules identifies hepcidin antagonists.

  title={High-throughput screening of small molecules identifies hepcidin antagonists.},
  author={Eileen Fung and Priscilla Sugianto and Jason Hsu and Robert Damoiseaux and Tomas Ganz and Elizabeta Nemeth},
  journal={Molecular pharmacology},
  volume={83 3},
Anemia of inflammation (AI) is common in patients with infection, autoimmune diseases, cancer, and chronic kidney disease. Unless the underlying condition can be reversed, treatment options are limited to erythropoiesis-stimulating agents with or without intravenous iron therapy, modalities that are not always effective and can cause serious adverse effects. Hepcidin, the iron regulatory hormone, has been identified as a pathogenic factor in the development of AI. To explore new therapeutic… CONTINUE READING
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