• Corpus ID: 204854148

High-throughput screening of myxoid liposarcoma cell lines reveals survivin as a potential novel druggable target

  title={High-throughput screening of myxoid liposarcoma cell lines reveals survivin as a potential novel druggable target},
  author={Marieke A. de Graaff and Shruti Malu and Irma Guardiola and Alwine B. Kruisselbrink and Yvonne A. de Jong and Willem E Corver and Hans Gelderblom and Patrick Hwu and Torsten O. Nielsen and Alexander J. Lazar and Neeta Somaiah and Judith V.M.G. Bov{\'e}e},
1 Citations

Molecular signatures of tumor progression in myxoid liposarcoma identified by N-glycan mass spectrometry imaging

Findings mirror recent observations in colorectal cancer, breast cancer, ovarian cancer, and cholangiocarcinoma, and are in line with a general role of high-mannose glycans and higher-antennary complex-type glycans in cancer progression.



Establishment and characterization of a new human myxoid liposarcoma cell line (DL-221) with the FUS-DDIT3 translocation

The established DL-221 cell line is the only published available myxoid liposarcoma cell line that underwent spontaneous immortalization, without requiring SV40 transformation, and its xenograft model are unique and helpful tools to study the biology and novel potential-targeted treatment approaches.

Targeting survivin as a potential new treatment for chondrosarcoma of bone

Sensitivity to YM155, a survivin inhibitor currently in phase I/II clinical trial for other tumors, showed that especially TP53 mutant cell lines were sensitive, but no caspase 3/7 or PARP cleavage was observed, indicating that survivin is more involved in cell-cycle regulation than in apoptosis.

Survivin isoforms and clinicopathological characteristics in colorectal adenocarcinomas using real-time qPCR

AIM: To investigate three isoforms of survivin in colorectal adenocarcinomas. METHODS: We used the LightCycler Technology (Roche), along with a common forward primer and reverse primers specific

Cell division control by the Chromosomal Passenger Complex.

YM155 exerts a growth inhibitory effect on human osteosarcoma in vitro and in vivo.

It was found that YM155 inhibited cell proliferation, colony formation, migration and invasion, induced cell apoptosis, as well as increased caspase-3, -8 and -9 activity in the OS cell lines in a dose-dependent manner, suggesting thatYM155 has potential as a therapeutic agent for the treatment of OS.

Loss of heterozygosity and DNA ploidy point to a diverging genetic mechanism in the origin of peripheral and central chondrosarcoma

The results indicate that peripheral chondrosarcomas, arising secondarily to an exostosis, may obtain genetic alterations during malignant transformation, with subsequent genetic instability as demonstrated by a high percentage of LOH and a wide variation in ploidy status.

Regulatory mechanisms, expression levels and proliferation effects of the FUS–DDIT3 fusion oncogene in liposarcoma

It is concluded that FUS–DDIT3 is uniquely regulated at the transcriptional as well as the post‐translational level and that its expression level is important for MLS tumour development.

Identification of genes differentially expressed in TLS‐CHOP carrying myxoid liposarcomas

A PCR‐based subtractive hybridization technique was used to identify genes that are differentially expressed in TLS‐CHOP‐carrying MLS but not in normal fat tissue, and six myxoid‐liposarcoma‐associated transcripts, MLAT, were isolated.