Corpus ID: 204854148

High-throughput screening of myxoid liposarcoma cell lines reveals survivin as a potential novel druggable target

@inproceedings{Graaff2017HighthroughputSO,
  title={High-throughput screening of myxoid liposarcoma cell lines reveals survivin as a potential novel druggable target},
  author={Marieke A. de Graaff and Shruti Malu and Irma Guardiola and Alwine B Kruisselbrink and Yvonne A. de Jong and Willem E Corver and Hans Gelderblom and Patrick Hwu and Torsten O. Nielsen and Alexander J. Lazar and Neeta Somaiah and Judith V.M.G. Bov{\'e}e},
  year={2017}
}
1 Citations
Molecular signatures of tumor progression in myxoid liposarcoma identified by N-glycan mass spectrometry imaging
TLDR
Findings mirror recent observations in colorectal cancer, breast cancer, ovarian cancer, and cholangiocarcinoma, and are in line with a general role of high-mannose glycans and higher-antennary complex-type glycans in cancer progression. Expand

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The established DL-221 cell line is the only published available myxoid liposarcoma cell line that underwent spontaneous immortalization, without requiring SV40 transformation, and its xenograft model are unique and helpful tools to study the biology and novel potential-targeted treatment approaches. Expand
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