High-throughput screening of dendrimer-binding drugs.

Abstract

A convenient approach for the high-throughput screening of dendrimer-binding drugs by NMR techniques including saturation transfer difference (STD) NMR and Hadamard-encoded nuclear Overhauser effect measurements is presented. The screening results for insoluble drugs show that phenylbutazone and sulfamethoxazole prefer to localize in the interior pockets of… (More)
DOI: 10.1021/ja106128u

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