High-throughput screening in embryonic stem cell-derived neurons identifies potentiators of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate-type glutamate receptors.

@article{McNeish2010HighthroughputSI,
  title={High-throughput screening in embryonic stem cell-derived neurons identifies potentiators of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate-type glutamate receptors.},
  author={John D. McNeish and Marsha Roach and John Hambor and Robert J Mather and Laura Weibley and John Lazzaro and Justin L Gazard and Jacob Schwarz and Robert A. Volkmann and D. Machacek and Steve S. Stice and Laura E Zawadzke and Christopher O'donnell and Raymond Hurst},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 22},
  pages={17209-17}
}
Stem cell biology offers advantages to investigators seeking to identify new therapeutic molecules. Specifically, stem cells are genetically stable, scalable for molecular screening, and function in cellular assays for drug efficacy and safety. A key hurdle for drug discoverers of central nervous system disease is a lack of high quality neuronal cells. In the central nervous system, alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate (AMPA) subtype glutamate receptors mediate the vast… CONTINUE READING

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High-throughput Screening in Stem Cell-derived Neurons

J. D. McNeish
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