High-throughput screening for modulators of cellular contractile force.

  title={High-throughput screening for modulators of cellular contractile force.},
  author={Chan Young Park and Enhua H Zhou and Dhananjay T Tambe and Bohao Chen and Tera Lavoie and Maria Dowell and Anton Simeonov and David J. Maloney and Aleksandar Marinkovi{\'c} and Daniel J Tschumperlin and Stephanie Burger and Matthew Frykenberg and James P. Butler and William Daniel Stamer and Mark Johnson and Julian Solway and Jeffrey J. Fredberg and Ramaswamy Krishnan},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  volume={7 10},
When cellular contractile forces are central to pathophysiology, these forces comprise a logical target of therapy. Nevertheless, existing high-throughput screens are limited to upstream signalling intermediates with poorly defined relationships to such a physiological endpoint. Using cellular force as the target, here we report a new screening technology and demonstrate its applications using human airway smooth muscle cells in the context of asthma and Schlemm's canal endothelial cells in the… CONTINUE READING
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