High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes.

@article{Charbord2013HighTS,
  title={High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes.},
  author={J{\'e}r{\'e}mie Charbord and Pauline Poydenot and Caroline Bonnefond and Maxime Feyeux and Fabrice Casagrande and Benjamin Brinon and Laetitia Francelle and Gwenna{\"e}lle Aur{\'e}gan and Martine Guillermier and Michel Cailleret and Pedro R. A. Vi{\'e}gas and Camille Nicoleau and C{\'e}cile Martinat and Emmanuel Brouillet and Elena Cattaneo and Marc Peschanski and Marc Lechuga and Anselme L. Perrier},
  journal={Stem cells},
  year={2013},
  volume={31 9},
  pages={1816-28}
}
Decreased expression of neuronal genes such as brain-derived neurotrophic factor (BDNF) is associated with several neurological disorders. One molecular mechanism associated with Huntington disease (HD) is a discrete increase in the nuclear activity of the transcriptional repressor REST/NRSF binding to repressor element-1 (RE1) sequences. High-throughput screening of a library of 6,984 compounds with luciferase-assay measuring REST activity in neural derivatives of human embryonic stem cells… CONTINUE READING

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