High-throughput screening and quantitative structure-efficacy relationship models of potential displacer molecules for ion-exchange systems.

Abstract

A technique is presented for the high-throughput screening of ion-exchange displacers. Potential displacers were employed to displace proteins in parallel batch ion-exchange experiments. The percentage of protein displaced from a particular stationary phase was then used as a parameter to rank the displacers. By employing this technique, a large number of… (More)

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