High-throughput screen of natural product extracts in a yeast model of polyglutamine proteotoxicity.

@article{Walter2014HighthroughputSO,
  title={High-throughput screen of natural product extracts in a yeast model of polyglutamine proteotoxicity.},
  author={Gladis M Walter and Avi Raveh and Sue-Ann Mok and Thomas J. McQuade and Carl J Arevang and Pamela J. Schultz and Matthew C. A. Smith and Samuel Asare and Patricia G Cruz and Susanne Wisen and Teatulohi K. Matainaho and David H. Sherman and Jason E. Gestwicki},
  journal={Chemical biology & drug design},
  year={2014},
  volume={83 4},
  pages={
          440-9
        }
}
Proteins with expanded polyglutamine (polyQ) segments cause a number of fatal neurodegenerative disorders, including Huntington's disease (HD). Previous high-throughput screens in cellular and biochemical models of HD have revealed compounds that mitigate polyQ aggregation and proteotoxicity, providing insight into the mechanisms of disease and leads for potential therapeutics. However, the structural diversity of natural products has not yet been fully mobilized toward these goals. Here, we… CONTINUE READING
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