High-throughput screen identifies cyclic nucleotide analogs that inhibit prostatic acid phosphatase.

@article{McCoy2013HighthroughputSI,
  title={High-throughput screen identifies cyclic nucleotide analogs that inhibit prostatic acid phosphatase.},
  author={Eric S. McCoy and Wendy A. Lea and Bryan T. Mott and David J. Maloney and Ajit Jadhav and Anton Simeonov and Mark J. Zylka},
  journal={Journal of biomolecular screening},
  year={2013},
  volume={18 4},
  pages={481-9}
}
The secretory and transmembrane isoforms of prostatic acid phosphatase (PAP) can dephosphorylate extracellular adenosine 5'-monophosphate (AMP) to adenosine, classifying PAP as an ectonucleotidase. Currently, there are no compounds that inhibit PAP in living cells. To identify small-molecule modulators of PAP, we used a 1536-well-based quantitative high… CONTINUE READING