High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury.

@article{Wills2013HighthroughputRA,
  title={High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury.},
  author={Lauren P. Wills and Gyda C Beeson and Richard E Trager and Christopher C Lindsey and Craig Cano Beeson and Yuri K. Peterson and Rick G Schnellmann},
  journal={Toxicology and applied pharmacology},
  year={2013},
  volume={272 2},
  pages={490-502}
}
Many environmental chemicals and drugs negatively affect human health through deleterious effects on mitochondrial function. Currently there is no chemical library of mitochondrial toxicants, and no reliable methods for predicting mitochondrial toxicity. We hypothesized that discrete toxicophores defined by distinct chemical entities can identify previously unidentified mitochondrial toxicants. We used a respirometric assay to screen 1760 compounds (5 μM) from the LOPAC and ChemBridge DIVERSet… CONTINUE READING