High-throughput rare cell separation from blood samples using steric hindrance and inertial microfluidics.

@article{Shen2014HighthroughputRC,
  title={High-throughput rare cell separation from blood samples using steric hindrance and inertial microfluidics.},
  author={Shaofei Shen and Chao Ma and Lei Zhao and Yaolei Wang and Jian-chun Wang and Juan Xu and Tianbao Li and Long Pang and Jinyi Wang},
  journal={Lab on a chip},
  year={2014},
  volume={14 14},
  pages={
          2525-38
        }
}
The presence and quantity of rare cells in the bloodstream of cancer patients provide a potentially accessible source for the early detection of invasive cancer and for monitoring the treatment of advanced diseases. The separation of rare cells from peripheral blood, as a "virtual and real-time liquid biopsy", is expected to replace conventional tissue biopsies of metastatic tumors for therapy guidance. However, technical obstacles, similar to looking for a needle in a haystack, have hindered… 
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