High-throughput profiling of alpha interferon- and interleukin-28B-regulated microRNAs and identification of let-7s with anti-hepatitis C virus activity by targeting IGF2BP1.

@article{Cheng2013HighthroughputPO,
  title={High-throughput profiling of alpha interferon- and interleukin-28B-regulated microRNAs and identification of let-7s with anti-hepatitis C virus activity by targeting IGF2BP1.},
  author={Min Hsuan Cheng and Youhui Si and Yuqiang Niu and Xiuying Y Liu and Xiang Li and Jin Zhao and Qi Jin and Wei Yang},
  journal={Journal of virology},
  year={2013},
  volume={87 17},
  pages={9707-18}
}
Hepatitis C virus (HCV) infection is a major cause of severe liver disease. Interferon (IFN)/ribavirin treatment remains the standard therapeutic regimen for HCV infection in most countries. IFN-stimulated genes are believed to contribute to antiviral effects. However, emerging evidence suggests that microRNAs (miRNAs), a class of noncoding small RNAs, are involved in the control of viral infection. Here, we systematically profiled the hepatocyte expression of a set of 750 miRNAs in response to… CONTINUE READING

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