High-throughput microcoil NMR of compound libraries using zero-dispersion segmented flow analysis.

@article{Kautz2005HighthroughputMN,
  title={High-throughput microcoil NMR of compound libraries using zero-dispersion segmented flow analysis.},
  author={Roger A Kautz and Wolfgang K Goetzinger and Barry L. Karger},
  journal={Journal of combinatorial chemistry},
  year={2005},
  volume={7 1},
  pages={
          14-20
        }
}
An automated system for loading samples into a microcoil NMR probe has been developed using segmented flow analysis. This approach enhanced 2-fold the throughput of the published direct injection and flow injection methods, improved sample utilization 3-fold, and was applicable to high-field NMR facilities with long transfer lines between the sample handler and NMR magnet. Sample volumes of 2 microL (10-30 mM, approximately 10 microg) were drawn from a 96-well microtiter plate by a sample… CONTINUE READING
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