High throughput methods of assessing protein stability and aggregation.

  title={High throughput methods of assessing protein stability and aggregation.},
  author={Guillermo A. Senisterra and Patrick J. Finerty},
  journal={Molecular bioSystems},
  volume={5 3},
The significant increase in the demand for purified protein for crystallization and structural studies has made necessary the development of multi-sample methods for identifying solution conditions that affect protein stability and aggregation. Conditions that stabilize proteins can improve protein purification and crystallization. These methods can be used to identify small molecule compounds or inhibitors that interact with the purified proteins, and might serve as starting points for drug… CONTINUE READING

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