High-throughput metabolic engineering: advances in small-molecule screening and selection.

@article{Dietrich2010HighthroughputME,
  title={High-throughput metabolic engineering: advances in small-molecule screening and selection.},
  author={Jeffrey A Dietrich and Adrienne E McKee and Jay D Keasling},
  journal={Annual review of biochemistry},
  year={2010},
  volume={79},
  pages={563-90}
}
Metabolic engineering for the overproduction of high-value small molecules is dependent upon techniques in directed evolution to improve production titers. The majority of small molecules targeted for overproduction are inconspicuous and cannot be readily obtained by screening. We provide a review on the development of high-throughput colorimetric… CONTINUE READING