High-throughput lectin magnetic bead array-coupled tandem mass spectrometry for glycoprotein biomarker discovery.

@article{Choi2011HighthroughputLM,
  title={High-throughput lectin magnetic bead array-coupled tandem mass spectrometry for glycoprotein biomarker discovery.},
  author={Eunju Choi and Dorothy Loo and J. W. Dennis and Caroline Ann O'Leary and Michelle M. Hill},
  journal={Electrophoresis},
  year={2011},
  volume={32 24},
  pages={3564-75}
}
Alterations in protein glycosylation occur during development and progression of many diseases, hence glycomics and glycoproteomics have emerged as important tools in glycobiomarker discovery. High-throughput glycan profiling can now be achieved with the recent developments in MS-based techniques. To enable identification and rapid monitoring of glycosylation changes in serum proteins, we developed a semi-automated high-throughput glycoprotein biomarker discovery platform termed lectin magnetic… CONTINUE READING
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