High-throughput imaging of neuronal activity in Caenorhabditis elegans.

  title={High-throughput imaging of neuronal activity in Caenorhabditis elegans.},
  author={Johannes Larsch and Donovan Ventimiglia and Cornelia I Bargmann and Dirk R Albrecht},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 45},
Neuronal responses to sensory inputs can vary based on genotype, development, experience, or stochastic factors. Existing neuronal recording techniques examine a single animal at a time, limiting understanding of the variability and range of potential responses. To scale up neuronal recordings, we here describe a system for simultaneous wide-field imaging of neuronal calcium activity from at least 20 Caenorhabditis elegans animals under precise microfluidic chemical stimulation. This increased… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 58 extracted citations


Publications referenced by this paper.
Showing 1-10 of 36 references

In vivo imaging of C. elegans ASH neurons: Cellular response and adaptation to chemical repellents

  • MA Hilliard
  • EMBO J 24(1):63–72
  • 2005
Highly Influential
6 Excerpts

Anthranilate fl uorescence marks a calciumpropagated necrotic wave that promotes organismal death in C . elegans

  • C Coburn
  • PLoS Biol
  • 2013

A micro fl uidic device for wholeanimal drug screening using electrophysiological measures in the nematode C . elegans

  • Lockery
  • Lab Chip
  • 2012

Similar Papers

Loading similar papers…