High-throughput imaging of neuronal activity in Caenorhabditis elegans.

@article{Larsch2013HighthroughputIO,
  title={High-throughput imaging of neuronal activity in Caenorhabditis elegans.},
  author={Johannes Larsch and Donovan Ventimiglia and Cornelia I Bargmann and Dirk R Albrecht},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 45},
  pages={
          E4266-73
        }
}
Neuronal responses to sensory inputs can vary based on genotype, development, experience, or stochastic factors. Existing neuronal recording techniques examine a single animal at a time, limiting understanding of the variability and range of potential responses. To scale up neuronal recordings, we here describe a system for simultaneous wide-field imaging of neuronal calcium activity from at least 20 Caenorhabditis elegans animals under precise microfluidic chemical stimulation. This increased… CONTINUE READING

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