High-throughput identification of catalytic redox-active cysteine residues.

@article{Fomenko2007HighthroughputIO,
  title={High-throughput identification of catalytic redox-active cysteine residues.},
  author={Dmitri E. Fomenko and Weibing Xing and Blakely M Adair and David J Thomas and Vadim N. Gladyshev},
  journal={Science},
  year={2007},
  volume={315 5810},
  pages={387-9}
}
Cysteine (Cys) residues often play critical roles in proteins; however, identification of their specific functions has been limited to case-by-case experimental approaches. We developed a procedure for high-throughput identification of catalytic redox-active Cys in proteins by searching for sporadic selenocysteine-Cys pairs in sequence databases. This method is independent of protein family, structure, and taxon. We used it to selectively detect the majority of known proteins with redox-active… CONTINUE READING

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