High-throughput identification of catalytic redox-active cysteine residues.

  title={High-throughput identification of catalytic redox-active cysteine residues.},
  author={Dmitri E. Fomenko and Weibing Xing and Blakely M Adair and David J Thomas and Vadim N. Gladyshev},
  volume={315 5810},
Cysteine (Cys) residues often play critical roles in proteins; however, identification of their specific functions has been limited to case-by-case experimental approaches. We developed a procedure for high-throughput identification of catalytic redox-active Cys in proteins by searching for sporadic selenocysteine-Cys pairs in sequence databases. This method is independent of protein family, structure, and taxon. We used it to selectively detect the majority of known proteins with redox-active… CONTINUE READING

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Publications referenced by this paper.
Showing 1-10 of 18 references

Its Molecular Biology and Role in Human Health

D L Hatfield, M J Berry, V N Gladyshev, Selenium
Its Molecular Biology and Role in Human Health • 2006

Annu. Rev. Pharmacol. Toxicol

J D Hayes, J U Flanagan, I R Jowsey
Annu. Rev. Pharmacol. Toxicol • 2005

Environ. Chem

B M Adair
Environ. Chem • 2005

J. Bacteriol

C Dahl
J. Bacteriol • 2005

PLoS Biol

H Y Kim, V N Gladyshev
PLoS Biol • 2005


S G Tringe
Science • 2005

Toxicol. Appl. Pharmacol

J Li
Toxicol. Appl. Pharmacol • 2005

Chem. Res. Toxicol

S B Waters, M Styblo, D J Thomas
Chem. Res. Toxicol • 2004

J. Mol. Biol

J R Cupp-Vickery, J J Silberg, D T Ta, L E Vickery
J. Mol. Biol • 2004


D E Fomenko, V N Gladyshev
Biochemistry • 2003

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