High-throughput identification of antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) and the transglycosylase.

@article{Cheng2010HighthroughputIO,
  title={High-throughput identification of antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) and the transglycosylase.},
  author={Ting-Jen Rachel Cheng and Ying-Ta Wu and Shih-Ting Yang and Kien-Hock Lo and Shao-Kang Chen and Yin-Hsuan Chen and W. Huang and Chih-Hung Yuan and C Guo and Lin-Ya Huang and Kuo-Ting Chen and Hao-Wei Shih and Y E Cheng and Wei-Chieh Cheng and C. -H. Wong},
  journal={Bioorganic & medicinal chemistry},
  year={2010},
  volume={18 24},
  pages={8512-29}
}
To identify new transglycosylase inhibitors with potent anti-methicillin-resistant Staphylococcus aureus (MRSA) activities, a high-throughput screening against Staphylococcus aureus was conducted to look for antibacterial cores in our 2M compound library that consists of natural products, proprietary collection, and synthetic molecules. About 3600 hits were identified from the primary screening and the subsequent confirmation resulted in a total of 252 compounds in 84 clusters which showed anti… CONTINUE READING