High-throughput generation, optimization and analysis of genome-scale metabolic models

@article{Henry2010HighthroughputGO,
  title={High-throughput generation, optimization and analysis of genome-scale metabolic models},
  author={Christopher S. Henry and Matthew DeJongh and Aaron A. Best and Paul Frybarger and Ben Linsay and Rick L. Stevens},
  journal={Nature Biotechnology},
  year={2010},
  volume={28},
  pages={977-982}
}
Genome-scale metabolic models have proven to be valuable for predicting organism phenotypes from genotypes. Yet efforts to develop new models are failing to keep pace with genome sequencing. To address this problem, we introduce the Model SEED, a web-based resource for high-throughput generation, optimization and analysis of genome-scale metabolic models. The Model SEED integrates existing methods and introduces techniques to automate nearly every step of this process, taking ∼48 h to… Expand

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