High-throughput functional screening for autophagy-related genes and identification of TM9SF1 as an autophagosome-inducing gene

@article{He2009HighthroughputFS,
  title={High-throughput functional screening for autophagy-related genes and identification of TM9SF1 as an autophagosome-inducing gene},
  author={Pengfei He and Z. Peng and Y. Luo and L. Wang and P. Yu and Weiwei Deng and Y. An and T. Shi and D. Ma},
  journal={Autophagy},
  year={2009},
  volume={5},
  pages={52 - 60}
}
  • Pengfei He, Z. Peng, +6 authors D. Ma
  • Published 2009
  • Biology, Medicine
  • Autophagy
    • Autophagy is a tightly regulated process responsible for the bulk degradation of most long-lived proteins and some organelles, which is associated with several forms of human disease including cancer, neurodegenerative disease, and cardiomyopathies. However, the molecular machinery involved in autophagy in mammalian cells remains poorly understood. Here, we describe a high-throughput, cell-based functional screening platform based on automated fluorescence microscopy system, that enable… CONTINUE READING
    View on Taylor & Francis
    tandfonline.com
    62 Citations
    Highly Influencial Citations
    2
    Background Citations
    21
    Methods Citations
    3
    62 Citations
    Citation Type

    Citation Type

    Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator
    • 48
    In Vitro Screening Platforms for Identifying Autophagy Modulators in Mammalian Cells.
    • 6
    Autophagy regulatory molecule, TMEM74, interacts with BIK and inhibits BIK-induced apoptosis.
    • 11
    DHRSX, A Novel Non-Classical Secretory Protein Associated With Starvation Induced Autophagy
    • 6
    • PDF
    TMEM74 promotes tumor cell survival by inducing autophagy via interactions with ATG16L1 and ATG9A
    • 9
    • Highly Influenced
    • PDF
    Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB4) as a Novel Autophagy Regulator by High Content shRNA Screening
    • 29
    • PDF
    A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy
    • 40
    PHF23 (plant homeodomain finger protein 23) negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1
    • 12
    What We Learned From Big Data for Autophagy Research
    • 6
    • PDF
    MARCH2 regulates autophagy by promoting CFTR ubiquitination and degradation and PIK3CA-AKT-MTOR signaling
    • 18