High-throughput determination of identity, purity, and quantity of combinatorial library members using LC/MS/UV/ELSD.

Abstract

We have used a high-throughput LC/MS/UV/ELSD method to rapidly determine the absolute quantity and purity of 42 organic compounds from seven lead discovery libraries. A general calibration curve generated from a different set of 42 compounds with seven different scaffolds was used in this analysis. We have also studied 33 organic compounds with different… (More)

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