High-throughput crystallography for lead discovery in drug design

@article{Blundell2002HighthroughputCF,
  title={High-throughput crystallography for lead discovery in drug design},
  author={Tom Leon Blundell and Harren Jhoti and Chris Abell},
  journal={Nature Reviews Drug Discovery},
  year={2002},
  volume={1},
  pages={45-54}
}
Knowledge of the three-dimensional structures of protein targets now emerging from genomic data has the potential to accelerate drug discovery greatly. X-ray crystallography is the most widely used technique for protein structure determination, but technical challenges and time constraints have traditionally limited its use primarily to lead optimization. Here, we describe how significant advances in process automation and informatics have aided the development of high-throughput X-ray… CONTINUE READING
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