High-throughput crystallography for lead discovery in drug design

  title={High-throughput crystallography for lead discovery in drug design},
  author={Tom Leon Blundell and Harren Jhoti and Chris Abell},
  journal={Nature Reviews Drug Discovery},
Knowledge of the three-dimensional structures of protein targets now emerging from genomic data has the potential to accelerate drug discovery greatly. X-ray crystallography is the most widely used technique for protein structure determination, but technical challenges and time constraints have traditionally limited its use primarily to lead optimization. Here, we describe how significant advances in process automation and informatics have aided the development of high-throughput X-ray… CONTINUE READING
Highly Cited
This paper has 178 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper


Publications citing this paper.
Showing 1-10 of 91 extracted citations

High Throughput Protein Crystallography

View 24 Excerpts
Method Support
Highly Influenced

Structural biology in antiviral drug discovery.

Current opinion in pharmacology • 2016
View 4 Excerpts
Highly Influenced

Structure-Based Drug Discovery

Methods in Molecular Biology • 2012
View 4 Excerpts
Highly Influenced

Structural genomics and drug discovery

Journal of cellular and molecular medicine • 2007
View 3 Excerpts
Highly Influenced

Small Molecule — Protein Interactions

Ernst Schering Research Foundation Workshop • 2003
View 3 Excerpts
Highly Influenced

A pipeline approach to single-particle processing in RELION

Acta crystallographica. Section D, Structural biology • 2017
View 1 Excerpt

179 Citations

Citations per Year
Semantic Scholar estimates that this publication has 179 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 70 references

Development for automation and miniaturisation of protein crystallisation

U Mueller
J. Biotechnol • 2001

High-throughput docking for lead generation.

Current opinion in chemical biology • 2001

Intrinsic fluorescence as a rapid scoring tool for protein crystals

A. N. Asanov, H. M. McDonald, P. B. Oldham, M. J. Jedrezejas, W. W. Wilson
J. Cryst. Growth • 2001

Macromolecular structure determination in the post genomic era

P. Kuhn, S. M. Soltis
Nucl. Instrum. Methods Phys. Res. A 467, • 2001