High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease

@inproceedings{Walker2010HighthroughputCL,
  title={High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease},
  author={Alan W Walker and Jeremy David Sanderson and Carol M Churcher and Gareth C. Parkes and Barry N. Hudspith and Neil B. Rayment and Jonathan Brostoff and Julian Parkhill and Gordon Dougan and Liljana Petrovska},
  booktitle={BMC Microbiology},
  year={2010}
}
The gut microbiota is thought to play a key role in the development of the inflammatory bowel diseases Crohn's disease (CD) and ulcerative colitis (UC). Shifts in the composition of resident bacteria have been postulated to drive the chronic inflammation seen in both diseases (the "dysbiosis" hypothesis). We therefore specifically sought to compare the mucosa-associated microbiota from both inflamed and non-inflamed sites of the colon in CD and UC patients to that from non-IBD controls and to… CONTINUE READING
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