High-throughput carbohydrate microarray profiling of 27 antibodies demonstrates widespread specificity problems.

@article{Manimala2007HighthroughputCM,
  title={High-throughput carbohydrate microarray profiling of 27 antibodies demonstrates widespread specificity problems.},
  author={Joseph C Manimala and Timothy A Roach and Zhitao Li and Jeffrey C Gildersleeve},
  journal={Glycobiology},
  year={2007},
  volume={17 8},
  pages={17C-23C}
}
Progress toward understanding the biological roles of carbohydrates has been remarkably slow, and efforts to exploit this class of biopolymers as diagnostic and therapeutic targets have proven extremely challenging. Both basic and clinical research rely heavily on identifying and monitoring expression levels of carbohydrates. Over the last 30 years, the majority of expression information has been derived from antibody- and lectin-binding studies. Using a carbohydrate microarray containing 80… CONTINUE READING

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