High-throughput analysis of immunoglobulin G glycosylation.

  title={High-throughput analysis of immunoglobulin G glycosylation.},
  author={Irena Trbojevi{\'c}-Akma{\vc}i{\'c} and Marija Vilaj and Gordan Lauc},
  journal={Expert review of proteomics},
  volume={13 5},
INTRODUCTION Glycosylation of immunoglobulin G (IgG) is important for its effector functions and was shown to be related to age, sex and disease status of an individual. Adding glycomic information to genome-wide association studies (GWAS) and large clinical trials is enabling insight into the functional relevance of changes in glycosylation, as well as molecular mechanisms behind these changes. Large-scale studies require sensitive, robust and affordable high-throughput methodologies for… CONTINUE READING
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