High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion

@inproceedings{Lehtinen2013HighthroughputRS,
  title={High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion},
  author={Laura Lehtinen and Kirsi Ketola and Rami M{\"a}kel{\"a} and John-Patrick Mpindi and Miro Viitala and Olli Kallioniemi and Kristiina Iljin},
  booktitle={Oncotarget},
  year={2013}
}
Vimentin is an intermediate filament protein, with a key role in the epithelial to mesenchymal transition as well as cell invasion, and it is often upregulated during cancer progression. However, relatively little is known about its regulation in cancer cells. Here, we performed an RNA interference screen followed by protein lysate microarray analysis in bone metastatic MDA-MB-231(SA) breast cancer cells to identify novel regulators of vimentin expression. Out of the 596 genes investigated… CONTINUE READING
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