High-temperature requirement protein A4 (HtrA4) suppresses the fusogenic activity of syncytin-1 and promotes trophoblast invasion.

@article{Wang2012HightemperatureRP,
  title={High-temperature requirement protein A4 (HtrA4) suppresses the fusogenic activity of syncytin-1 and promotes trophoblast invasion.},
  author={Liang-Jie Wang and Mei-Leng Cheong and Yun-Shien Lee and Ming-Ting Lee and Hungwen Chen},
  journal={Molecular and cellular biology},
  year={2012},
  volume={32 18},
  pages={
          3707-17
        }
}
Cell-cell fusion and cell invasion are essential for placental development. Human cytotrophoblasts in the chorionic villi may undergo cell-cell fusion to form syncytiotrophoblasts to facilitate nutrient-gas exchange or differentiate into extravillous trophoblasts (EVTs) to facilitate maternal-fetal circulation. The placental transcription factor glial cells missing 1 (GCM1) regulates syncytin-1 and -2 expression to mediate trophoblast fusion. Interestingly, GCM1 and syncytin-1 are also… CONTINUE READING

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