High telomerase activity in granulocytes from clonal polycythemia vera and essential thrombocythemia.

@article{Ferraris2005HighTA,
  title={High telomerase activity in granulocytes from clonal polycythemia vera and essential thrombocythemia.},
  author={Anna Maria Ferraris and Rosa Mangerini and Natalija Pujic and Omar Racchi and Davide Rapezzi and Andrea Gallamini and Salvatore Casciaro and Gian Franco Gaetani},
  journal={Blood},
  year={2005},
  volume={105 5},
  pages={
          2138-40
        }
}
Essential thrombocythemia (ET) and polycythemia vera (PV) are chronic myeloproliferative disorders that share the involvement of a multipotent progenitor cell and dominance of the transformed clone over normal hematopoiesis. On the other hand, the heterogeneity of these diseases with respect to clonal development from a common progenitor has been well established. To identify useful prognostic indicators, we analyzed telomerase activity (TA), a known marker of neoplastic proliferation, in… 
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Clonal granulocytes in polycythaemia vera and essential thrombocythaemia have shortened telomeres
The purpose of this study was to evaluate telomere length in peripheral blood granulocytes and mononuclear cells collected from 22 women with polycythaemia vera (PV) and essential thrombocythaemia…
Polycythemia vera: new clinicopathologic perspectives.
TLDR
Modified clinical, histologic, and laboratory criteria have clarified the diagnosis of Polycythemia vera and continuing studies on the recently discovered JAK2V617F gene mutation may significantly improve the understanding of PV pathogenesis and facilitate its medical management.
New Clinicopathologic Perspectives
TLDR
Modified clinical, histologic, and laboratory criteria have clarified the diagnosis of PV and continuing studies on the recently discovered JAK2V617F gene mutation may significantly improve the understanding of PV pathogenesis and facilitate its medical management.
Telomere shortening in Ph-negative chronic myeloproliferative neoplasms: a biological marker of polycythemia vera and myelofibrosis, regardless of hydroxycarbamide therapy.
The expression levels of telomerase catalytic subunit hTERT and oncogenic MYC in essential thrombocythemia are affected by the molecular subtype
TLDR
The functional link between MYC and hTERT seems to be impaired depending on the molecular ET subtype, which in turn may have implications on the phenotype and course of the disease.
Dynamics of telomere's length and telomerase activity in Philadelphia chromosome negative myeloproliferative neoplasms.
Telomere length is severely and similarly reduced in JAK2V617F-positive and -negative myeloproliferative neoplasms
Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized by chronic proliferation of hematopoietic progenitors. We studied the telomere length (TL) of 335 MPN patients and 93…
The importance of the telomere and telomerase system in hematological malignancies
TLDR
The biological, diagnostic and prognostic value of telomere/telomerase biology is discussed, as well as its potential future applications in cancer therapeutics.
Telomere length dynamics in normal hematopoiesis and in disease states characterized by increased stem cell turnover
TLDR
Data from congenital disorders, like dyskeratosis congenita (DKC), suggest that disturbed telomere maintenance may play a role for replicative exhaustion of the HSC pool in vivo, and data from normal steady-state hematopoiesis provided the basis for follow-up studies in model scenarios characterized by increased HSC turnover.
Telomere and telomerase in hematologicalmalignancies.
TLDR
The importance of clinicopathologic significance of telomerase in cancer and the details of the mechanisms regulating its activity remain to be clarified.
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TLDR
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