High systemic bone mineral density increases the risk of incident knee OA and joint space narrowing, but not radiographic progression of existing knee OA: the MOST study

@article{Nevitt2010HighSB,
  title={High systemic bone mineral density increases the risk of incident knee OA and joint space narrowing, but not radiographic progression of existing knee OA: the MOST study},
  author={Michael C. Nevitt and Yun-hui Zhang and Mk. Javaid and Tuhina Neogi and Jeffrey R. Curtis and Jingbo Niu and Charles E. McCulloch and Neil A. Segal and David T. Felson},
  journal={Annals of the Rheumatic Diseases},
  year={2010},
  volume={69},
  pages={163 - 168}
}
Objectives: Previous studies suggest that high systemic bone mineral density (BMD) is associated with incident knee osteoarthritis (OA) defined by osteophytes but not with joint space narrowing (JSN), and are inconsistent regarding BMD and progression of existing OA. The association of BMD with incident and progressive tibiofemoral OA was tested in a large prospective study of men and women aged 50–79 years with or at risk for knee OA. Methods: Baseline and 30-month weight-bearing… Expand
Associations between systemic bone mineral density and early knee cartilage changes in middle-aged adults without clinical knee disease: a prospective cohort study
TLDR
In middle-aged people without clinical knee disease, higher systemic BMD was associated with increased early knee cartilage damage and increased rate of lateral tibial cartilage volume loss. Expand
The Relationship between Osteoarthritis of the Knee and Bone Mineral Density of Proximal Femur: A Cross-Sectional Study from a Korean Population in Women
TLDR
The radiographic finding of severe OA in the knee is associated with decreased BMD of the ipsilateral proximal femur including the femoral neck, trochanter, intertrochanter and region of the entire hip. Expand
Individuals with High Bone Mass have increased progression of radiographic and clinical features of knee osteoarthritis.
TLDR
High bone mass is associated with osteophyte progression, which appears to contribute to increased reported pain, stiffness and functional loss, and HBM individuals had higher WOMAC knee pain scores. Expand
Association of bone mineral density with the development of knee osteoarthritis in men and women: a cross-sectional study using the fourth and fifth Korea National Health and Nutrition Examination Surveys
Summary Bone mineral density (BMD) and osteoarthritis (OA) were correlated but the relationship was varied according to sex. An association between lumbar spine and femur neck BMDs and OA showed aExpand
Knee osteoarthritis is associated with increased prevalence of vertebral fractures despite high systemic bone mineral density: a cross-sectional study in an Asian population
TLDR
It is suggested that bone quality, and consequently bone strength, may be decreased at the systemic level in knee osteoarthritis. Expand
Running title : bone mineral density , fractures and osteoarthritis
Objective. To examine the longitudinal relationship between bone mineral density (BMD) and the incidence and progression of knee, hip and hand osteoarthritis, and the relationship between prevalentExpand
Relationship of Bone Mineral Density and Knee Osteoarthritis (Kellgren-Lawrence Grade): Fifth Korea National Health and Nutrition Examination Survey
TLDR
No significant association was found between OA and the following variables: white blood cell, platelet, total cholesterol, vitamin D, alkaline phosphatase, parathyroid hormone, hypertension, diabetes, asthma, dyslipidemia, smoking status, alcohol consumption, and regular exercise. Expand
Individuals with high bone mass have an increased prevalence of radiographic knee osteoarthritis
TLDR
A positive association between high bone mass and knee OA is supported, suggesting HBM confers a general predisposition to a subtype of OA characterised by increased bone formation. Expand
Bone mineral density and association of osteoarthritis with fracture risk.
TLDR
Women with OA have an increased risk of fragility fracture, and the risk was mainly observed in non-osteoporotic group. Expand
High Bone Mass is associated with bone-forming features of osteoarthritis in non-weight bearing joints independent of body mass index
TLDR
HBM is positively associated with OA in non-weight-bearing joints, independent of BMI, and HBM-associated OA is characterised by osteophytes, consistent with a bone-forming phenotype, rather than JSN reflecting cartilage loss. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 86 REFERENCES
Bone mineral density and risk of incident and progressive radiographic knee osteoarthritis in women: the Framingham Study.
TLDR
BMD change was not associated with osteophyte development, but gain in BMD lowered the risk of joint space loss, and high BMD and BMD gain decreased therisk of progression of radiographic knee OA, but may be associated with an increased risk of incident knee Oa. Expand
Association of radiographically evident osteoarthritis with higher bone mineral density and increased bone loss with age. The Rotterdam Study.
TLDR
Radiographic OA is associated with high BMD and increased rate of bone loss with age, which suggests a more pronounced difference in BMD earlier in life. Expand
The relationship of bone density and fracture to incident and progressive radiographic osteoarthritis of the knee: the Chingford Study.
TLDR
For women who develop incident knee OA, defined by osteophytes, BMD is higher and of a magnitude similar to that shown in cross-sectional studies, and a possible common role of bone turnover and repair in the early manifestations of OA is suggested. Expand
Bone mineral density and vertebral fracture history are associated with incident and progressive radiographic knee osteoarthritis in elderly men and women: the Rotterdam Study.
TLDR
High systemic BMD at baseline is associated with increased incidence and progression of knee ROA in both men and women, while a prevalent vertebral fracture has a protective effect. Expand
The associations of bone mineral density and bone turnover markers with osteoarthritis of the hand and knee in pre- and perimenopausal women.
TLDR
It is suggested that bone-forming cells might show a differential response in OA of the hand and knee, and may suggest a different pathogenesis of hand OA and knee OA. Expand
Radiographic osteoarthritis of the hip and bone mineral density. The Study of Osteoporotic Fractures Research Group.
TLDR
Elderly Caucasian women with moderate to severe radiographic hip OA had higher BMD in the hip, spine, and appendicular skeleton than did women without hip OO, and these findings are consistent with a role of elevated B MD in the pathogenesis of Hip OA. Expand
Distribution of Bone Mineral Density at the Proximal Tibia in Knee Osteoarthritis
TLDR
Asymmetry of the knee BMD distribution revealed that progression of the deformity (either varus or valgus) with joint space narrowing led to an increase in the medio-lateral difference of the proximal tibia density. Expand
A cotwin control study of the relationship between hip osteoarthritis and bone mineral density.
TLDR
This twin study confirms the existence of an inverse relationship between OA and OP at the hip, however, the relationship was localized to the OA-affected hip and suggests that local changes in bone density may be a component of the disease process in hip OA. Expand
Bone mineral density and osteoarthritis: data from the Baltimore Longitudinal Study of Aging.
TLDR
Data from the Baltimore Longitudinal Study of Aging demonstrate that persons with radiographic OA lose bone at different rates than those with normal radiographs and that this relationship varies between the sites of OA and the site of measurement of BMD. Expand
The role of knee alignment in disease progression and functional decline in knee osteoarthritis.
TLDR
This is the first demonstration that in primary knee OA varus alignment increases risk of medial OA progression, that valgus alignment increased risk of lateral OA progress, that burden of malalignment predicts decline in physical function, and that these effects can be detected after as little as 18 months of observation. Expand
...
1
2
3
4
5
...